Well, Isaac was the son of Abraham. His father almost killed him but an angel intervened. Rebecca was his wife, discovered at a well where she offered water to Abraham's servant who was on a hunt for Isaac's bride. (Gen. 24)
Isaac and Rebecca were parents of twins Jacob and Esau, and Jacob fathered the 12 sons who became the beginnings of the 12 tribes of Israel. (They also had a sister, Dinah, but she doesn't get much ink in the story.)