I don’t know. I think the Axe/Chuck thing started with chuck being an attorney for the Southern District and Axe was the type of crook they go after. He became obsessed and did whatever was necessary to bring Axe down, even crossing ethical lines which did a lot of damage.
They called a truce for awhile and Axe now seems to think he’s a mob boss with everyone at his beck and call. Chuck is seeing all trouble starting with Axe and Axe has become a monster needing to be taken down.
Axe is way more vile and disgusting and dangerous than any of the others. He doesn’t lose any sleep over destroying lives, destroying thousands of people’s livelihoods, even murder. Chuck isn’t even in that same league.