I could have quoted more of these same comments through the thread, but then I'd be quoting like 85% of the thread.
I struggle with major depressive disorder, and, honestly, how Jo is behaving is pretty much the same way I spiral when something bad happens in my life. I was going to say that the portrayal of Jo drinking bothers me because it blurs the storyline between alcoholism and depression, except I just realized that I used to use alcohol as a coping mechanism, until I quit drinking altogether.
When I am depressed, I can barely be bothered to shower or even brush my teeth more than once a week. I push away the people who love me and refuse to talk about what I'm going through, because nobody else could possibly understand (or so the depression tells me). I hate myself and often would turn that outward (especially while drinking) and unleash on those who love me, saying terrible things. And, oh, the anger! I'd be furious with myself for making the decisions leading to my current situation, which would often lead to me snapping at others. If anyone said they would give me consequences for my actions, my response would basically be "go fuck yourself, I don't care." And I truly didn't. I felt I didn't deserve anyone's love and that I was a burden on everyone (again, that was the depression talking). I would do everything I could to sabotage everything good in my life, because the depression told me I didn't deserve any of it.
So Jo's behavior rings true to me. The problem is, that's a really hard story to tell in 3-minute scenes at a time, when the depressed person doesn't want to talk to anyone and tell them what's in her head. The last time I spiraled, I finally broke down and realized what I was doing wasn't working for me after I had two anxiety attacks--which had never happened to me before. So I think they are moving towards her having a break down of sorts, since being drunk at work is an escalation of behaviors. But since it's so hard to explain to the audience what she's going through *right now*, the break down won't necessarily be as satisfying and cathartic for the audience.
Jo has had a lot of trauma in her life and she never has gotten help to process and heal from those things. Achieving so much despite the odds does not magically heal all the trauma. I cannot imagine what it would feel like to learn that you are the product of rape, but I could see how that would trigger you to feel that the violence of your conception means you deserved all of the terrible things you've experienced in your life. So now that her life has good things in it, she thinks she doesn't deserve those things and is sabotaging it all.
Those above who said that this isn't going to wrap up by season end, you're right. Even though the writers have not done a great job with this part of the story, I think (hope!) once her breakdown moment comes, they will find it easier to write the rest and do this story justice. I could see Jo in therapy next season, working through all the trauma she's experienced in her life. Also, I don't see her leaving Alex--even though this show can be totally ridiculous, I can't see Alex's second wife disappearing from the face of the earth just like his first wife.