Heather gives Ava some of her LSD-spiked iced tea. Ava goes cuckoo for Cocoa Puffs, and, thinking Sonny is AJ back from the dead again, shoots and kills him. Ava, who also confesses to shooting Connie, gets sent to lockdown at Ferncliff, never to be seen again. Sonny's funeral is sparsely attended after the truth about him shooting AJ is revealed. Carly's role in keeping Sonny's secret is also revealed, and Michael turns his back on her. Kiki and Michael quarrel over this, and Kiki leaves town.
In a final, epic Spencer-Cassadine battle, Luke gets a redemption storyline. Victor and Helena take their battle for power to Port Charles, where an epidemic is unleashed on the city. Franco, Sabrina, Felix, and Olivia are among the dead. Joss, Anna, Obrecht, Julian, and Nikolas are among the ill. It's up to Robert and Luke to figure things out and track down the Cassadines to get the cure. Luke is shot but kills Helena and Victor really, truly, finally, dead. He and Laura have a final goodbye, with loads of flashbacks of the glory days, as they express their gratitude for everything they had together. Luke dies holding the hands of Lulu and Lucky, while Tracy holds him in her arms. There is a huge memorial for him, as family and friends from the past gather. Pallbearers include Robert, Lucky, Ethan, Lucas, Morgan, and Michael.
Maxie returns with her baby, after Spinelli is killed in a car accident. She settles back in Port Charles and tries to rebuild her life as a mother.
Carly leaves town after Joss' complications from the epidemic require specialized treatment overseas. Michael comes to say goodbye to Joss, but snubs Carly. Other than Bobbie and Morgan, no one else bothers to say goodbye to Carly. She sobs as the plane takes off.
With Victor dead, Robin is free from his threats. She returns home, telling Patrick she turned off Stavros' life support, killing him. Unfortunately, Jason was too far gone to save. She is able to bring his body home. Sam has him cremated. Half of the ashes, Sam and Robin scatter from the bridge in memory of Jason Morgan. The other half of the ashes are given to Monica, to be buried in the Quartermaine crypt as Jason Quartermaine. AJ returns home for the private service, telling Tracy that he sold his shares of ELQ to Monica and Michael. She can deal with them, he's done with her. He sabotages the MetroCourt while Carly is overseas, ruining her investment and forcing her to sell out. He buys it through a shadow company he created, and renames it Quartermaine Plaza. He hires Morgan to run the health club at the hotel. Maxie gets a job running guest services.
Obrecht loses whatever leverage she had after Victor dies, and she's demoted at GH. Monica assumes power as chief of staff. She names Patrick as chief of surgery, and Robin as chief of immunology.