Yeah, for somebody who’s germaphobic and doesn’t generally like touching or being around random people, Sheldon would be fine with that more than he would be annoyed with his change in routine. Plus, he can clearly adapt to new routines, otherwise he’d have never moved to California in the first place.
i wonder more about some of the others. Penny can’t exactly do pharmaceutical sales right now. Amy and Bernadette would still have been going to work, since theirs is medical.