Shrill Harpy gets my vote.
One particular episode that bugged me was 'Ally's F'. Ally had good grades in all her classes except Math. Debra was hellbent on Ally being the problem when any realistic person would conclude something else must be going on if she was excelling in her other classes. It took the teacher being rude to her towards the end of the episode before she finally ruled him as the problem. The whole thing irked me.
Also, she knew how intrusive Ray's family was before marrying him. That was the same family who interrupted their date night - even bringing the priest along- in a flashback episode. That's nowhere near normal and should've been an instant red flag. In another flashback (after they were married but still living in an apartment), Marie was trying to break down the door to tell Ray the pregnancy news before Debra could get the chance. But Debra still insisted on living right across the street from them...regardless of all the red flags, topped by Ray's warning about it. That could be why he wasn't compelled to fight battles for her once she got fed up with the family because he felt she had already been warned by him. Maybe subconsciously he also resented her for it.
Ray used work as a temporary escape from Debra. I felt bad for him when she started insisting he work from home in one episode. Yes, he could be a man child but the man could do NO right as far as she was concerned. Even in the 'Annoying Kid' episode when he was correcting that misbehaving child she didn't take his side. Well, at least not until that couple said something passive about their kids.
I saw the superbowl episode mentioned in here. I can somewhat understand why she felt slighted about not being asked. But then I can't really blame him because she was a wet blanket once he did fly her in. It was the SB but It was also a work related trip where it would be expected he would meet up with colleagues and rub elbows. It's like she wanted to turn it into their 2nd honeymoon.