I think her type of obesity does end up impacting your life in every way to some degree, but we have seen storylines for her where it wasn't the focus - such as her infertility treatment and pregnancy. Her weight factors in, but it wasn't a driving focus. Similar, when Toby had a heart attack, there wasn't much focus on her weight. Even her pursuit of a singing career, her weight was mentioned but it wasn't really the focus.
Overall, I think the show has handled it fairly delicately. Her storyline initially seemed like it was going to be a story of weight loss and when that didn't happen, the show adjusted.