Noooo, poor Max! He was becoming one of my favourites, so I'm hoping it's not permanent. Whereas Joe and Pete's wife are fully deserving of being pushed off a bridge (as would be David Elster if he was still alive).
Very intrigued as to where Karen fits in with all this, I'd guess she must be one of David's as nobody else seems that technologically advanced but it seems odd that the other ones wouldn't know about her. Unless he created her as a future girlfriend for Leo, because he did sound like a very odd man. I find the transitions with her a bit jarring, it's like she's very human when we're not supposed to think of her as a synth, but then very synth like when we're supposed to remember. It's subtler with the others.
Loved the way both the synth and human male came up with equally pitiful compliments.