I had the same experience with depression meds. Prozac was the first, did nothing to help, then began my depression med "journey," finally ended up on Wellbutrin which helped a lot, plus did not, fortunately, cause weight gain. No longer take any meds, and do well, except for SAD in the winter, which was particularly bad this year. California finally is drought free for the first time in 10 years, which made for a very dark, gloomy, and wet winter. I'm just now coming out of it.