I binged it, so I don't remember what happened in specific episodes. As the stepmother of a high-functioning autistic young man (who I saw through his teenage years), I really appreciated a lot about this show. I thought the portrayal of Sam's idiosyncrasies, coping mechanisms, and family's reactions as his needs moved away from the center of their lives were all very sensitive and well done (and as accurate as they could be, given the wide variation of how people on the spectrum present and the needs of the plot). I also very much enjoyed it as a show, and was surprised at how sweet and real the teenage daughter's various plots and relationships were and how invested I got in the non-Sam storylines. I've also never liked Michael Rappaport, but I really enjoyed him in this.
My biggest problem, and one I can't let go, is that Sam was obsessed with the Antarctic but occasionally they had him spout facts about polar bears or Arctic foxes or other animals from the COMPLETELY OPPOSITE POLE. I get that he had a thing for cold environments and wildlife in general, but they did specify that his obsession was Antarctica and penguins, so stuff about the Arctic should at the very least have gotten an asterisk or a comparison to his preferred region. The North Pole and the South Pole are different places with different wildlife. Anyone with his level of intelligence and fixation would never have made that mistake, and it drove me crazy that the writers got lazy and just inserted facts about animals they had seen in the snow.
ETA: Sam's friend at the tech store totally reminded me so much of Lester on Chuck that I had a hard time warming up to him. But he was sweet and did care for and seem to really get Sam, so I came to love him.